What is acromegaly?

It is the enlargement of the ends as a result of excessive release of growth hormone due to eosinophilic adenoma in the anterior pituitary.


Acromegaly symptoms and signs

• Headache
• Growth of hands and feet (enlargement of glove and shoe size)
• Enlargement of the nose, forward growth of the lower jaw
• The growth of the tongue
• Enlargement of internal organs
• Excessive sweating, weakness
• Dilution of teeth, thickening of lips
• Thickening, oily and small nodules in the skin
• Hoarseness
• Double vision
• Cessation of menstruation, lack of sexual desire in women
• Enlargement in anteroposterior diameter of the chest
• Hormone disorders such as goiter, diabetes, milk coming from the breasts in advanced cases


Studies on diagnosis of acromegaly

  • Growth hormone (increases) in serum
  • Inorganic phosphorus in serum (increases)
  • Insulin resistant rise in blood sugar and urine sugar
  • Increased calcium in urine (Hypercalciuria)
  • Sella radiography: enlargement of Sella
  • Spine radiography: Vertebral growth and osteophyte formation, dorsal kyphosis
  • Changes in hand and foot radiographs
  • Eye examination: narrowing of the visual field
  • The location and size of the tumor can be determined by computed tomography.


Acromegaly treatment

• Bromocriptine (reduces growth hormone level in acromegaly to normal.)
• Surgical treatment: If there is significant suprasellar tumor growth, the tumor is removed by transfrontal surgery, if the tumor is intrasellar, by transphenoidal surgery.
• Radiotherapy: a radioactive core is placed in the pituitary gland or external radiotherapy can be applied. It is not as effective as surgery and does not respond quickly.


Relevant specialty branch (s)

• Internal medicine – Endocrinology
• Brain and Nerve Surgery

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